tag:blogger.com,1999:blog-3904639295706642486.post287097447002140182..comments2023-10-21T08:48:37.363-07:00Comments on Zone-Reflex: Walking molecules.Unknownnoreply@blogger.comBlogger5125tag:blogger.com,1999:blog-3904639295706642486.post-31040393901409052612014-01-22T02:21:51.144-08:002014-01-22T02:21:51.144-08:00http://emboj.embopress.org/content/early/2014/01/1...http://emboj.embopress.org/content/early/2014/01/15/embj.201386030<br /><br />Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy<br />Tanveer Ahmad, Shravani Mukherjee, Bijay Pattnaik, Manish Kumar, Suchita Singh, Manish Kumar, Rakhshinda Rehman, Brijendra K Tiwari, Kumar A Jha, Amruta P Barhanpurkar, Mohan R Wani, Soumya S Roy, Ulaganathan Mabalirajan, Balaram Ghosh, Anurag Agrawal<br />DOI: 10.1002/embj.201386030 |Published 15.01.2014<br /><br />Abstract<br /><br />There is emerging evidence that stem cells can rejuvenate damaged cells by mitochondrial transfer. Earlier studies show that epithelial mitochondrial dysfunction is critical in asthma pathogenesis. Here we show for the first time that Miro1, a mitochondrial Rho‐GTPase, regulates intercellular mitochondrial movement from mesenchymal stem cells (MSC) to epithelial cells (EC). We demonstrate that overexpression of Miro1 in MSC (MSCmiroHi) leads to enhanced mitochondrial transfer and rescue of epithelial injury, while Miro1 knockdown (MSCmiroLo) leads to loss of efficacy. Treatment with MSCmiroHi was associated with greater therapeutic efficacy, when compared to control MSC, in mouse models of rotenone (Rot) induced airway injury and allergic airway inflammation (AAI). Notably, airway hyperresponsiveness and remodeling were reversed by MSCmiroHi in three separate allergen‐induced asthma models. In a human in vitro system, MSCmiroHi reversed mitochondrial dysfunction in bronchial epithelial cells treated with pro‐inflammatory supernatant of IL‐13‐induced macrophages. Anti‐inflammatory MSC products like NO, TGF‐β, IL‐10 and PGE2, were unchanged by Miro1 overexpression, excluding non‐specific paracrine effects. In summary, Miro1 overexpression leads to increased stem cell repair.<br />Ullahttps://www.blogger.com/profile/16634036177244152897noreply@blogger.comtag:blogger.com,1999:blog-3904639295706642486.post-11924641300437661842010-09-21T10:50:24.533-07:002010-09-21T10:50:24.533-07:00Nitrogen is surely a quantum gas. Look at the effe...Nitrogen is surely a quantum gas. Look at the effects of NO :)<br /><br />The different atoms and molecules form a network of negentropy, meaning (reduction) that is broken (oxidation).<br /><br />As I said Rowland has bad foundations. otherwise his thoughts are good, I think.<br /><br />I should index, I know. I started in swedish, then I noticed I must write in english and so it left. Sry.Ullahttps://www.blogger.com/profile/16634036177244152897noreply@blogger.comtag:blogger.com,1999:blog-3904639295706642486.post-60668420437125206132010-09-21T09:49:38.285-07:002010-09-21T09:49:38.285-07:00Ulla
Of course the hexagons are part of the diamo...Ulla<br /><br />Of course the hexagons are part of the diamond lattice- unless they are flat thus zero probability and organic aromatic principles (also found on buckyball surfaces)<br /><br />For my connection with Fermi surfaces I offer you only the photo of my blog on<br />http://4.bp.blogspot.com/_UF6vrnsBd3U/S4q-6V6W1LI/AAAAAAAAAaM/k8U6iIMS5_A/s1600-h/supersympx.jpg to show the geometry- but the depth of my understanding then is a little obsolete.<br /><br />Rowlands points out in DNA there can be alternative ways to stack it with four ways to understand where the sugar goes<br /><br />Nitrogen and in NH3 could certainly be a source of quantum flux in a mental or organic system or between synapses according to Wolfe.<br /><br />The vibration state if a carbon atom (methane and so on) has 15 possible ones observed. Where is the 16th (presumed superimposed)? But I see this as a matter of geometry and Venn logic.<br /><br />On should really see a carbon like structures as the five points of a four dimensional simplex (made of triangles).<br /><br />Such ideas may be had to see but easy to intuit so pardon if we are not on the same partical length :-) your interest in all this impresses me very much.<br /><br />This link may be of general interest to you too. <br /><br />http://pesla.blogspot.com/2010/04/casual-encounter-with-peter-rowlands.html<br /><br />I guess I should index stuff here as it was so much to try to find, but pictures help.<br /><br />ThePeSlaL. Edgar Ottohttps://www.blogger.com/profile/00525169618204198073noreply@blogger.comtag:blogger.com,1999:blog-3904639295706642486.post-41367374179308100762010-09-20T00:56:57.474-07:002010-09-20T00:56:57.474-07:00You know, I have some figures on my mind. Hexagons...You know, I have some figures on my mind. Hexagons are one. Also the important building blocks of Life, oxygen and hydrogen, metals, and their relations. If you put a carbon atom in each corner of the Fermi surface you have an important piece, modulated by methane. Why is it done in that way?<br />In sugars you get instead an pentagon. It is about forms as essential structures.Ullahttps://www.blogger.com/profile/16634036177244152897noreply@blogger.comtag:blogger.com,1999:blog-3904639295706642486.post-25206511893123767122010-09-19T16:32:35.091-07:002010-09-19T16:32:35.091-07:00Wish you would find the energy to continue.
Ulla, ...Wish you would find the energy to continue.<br />Ulla, a great post and a beautiful picture.<br />It inspired a coming together of some ideas today I think you can appriciate it and like the alternative view. See my post The Synthetic Engine.<br /><br />The PeSla pesla.blogspot.comL. Edgar Ottohttps://www.blogger.com/profile/00525169618204198073noreply@blogger.com